A Boeing 737 airliner with 104 passengers on board has crashed and exploded near Jose Marti International Airport in Havana.
Cuba's President Miguel Diaz-Canel, who is at the scene, said there appeared to have been a "high number" of casualties.
The death toll has not been confirmed.
A report from the Cuban Communist Party newspaper Granma said three people had survived, and are "in a critical state, in hospital".
The plane came down shortly after take-off, crashing in a field. State TV said nine foreign crew were on board as well as the passengers.
"There has been an unfortunate aviation accident. The news is not very promising, it seems that there is a high number of victims," Mr Diaz-Canel was quoted as saying.
The airliner had been leased by state airline Cubana de Aviación from the Mexican company Damojh, Cuban news agency Prensa Latina said.
State TV said it was an internal flight from the Cuban capital to the city of Holguin, in the east of the island.
Images showed a thick column of smoke rising above the crash site. Fire crews and ambulances are at the scene.
Radio Havana Cuba said on Twitter that the plane came down on the "highway" between Boyeros and Havana, near the airport.