The Red Cross (IFRC) says that it can begin distributing crucial aid supplies to crisis-hit Venezuela in two weeks.
IFRC head Francesco Rocca said the group could initially help 650,000 suffering a lack of food and medicine.
The government of President Nicolás Maduro and the opposition are both said to back the aid move.
Opposition leader Juan Guaidó said the government had "recognised its failure by accepting the existence of a complex humanitarian emergency".
In February, Mr Maduro used the military to block an effort led by Mr Guaidó to bring in US-backed humanitarian aid convoys.
Mr Guaidó, the head of the opposition-controlled National Assembly, declared himself interim president in January, winning the support of more than 50 countries, including the US.
Mr Maduro regarded the aid convoys as a veiled US invasion.
What has the Red Cross said?
Speaking at a news conference in Caracas, Mr Rocca said: "We estimate that in a period of approximately 15 days we will be ready to offer help. We hope to help 650,000 people at first."
Mr Rocca said Venezuela had met the conditions for humanitarian work to be carried out.
Mr Rocca said the IFRC would need to be able to act with "impartiality, neutrality and independence" and no interference.
Mr Guaidó said on Twitter that the IFRC announcement was a "great victory in our struggle".
The BBC's Will Grant says the agreement on aid is an implicit acknowledgement from President Maduro that there is indeed a humanitarian crisis in Venezuela, despite his repeated denials over recent years.
Mr Maduro has yet to comment publicly on the move but, our correspondent says, is likely to paint it as the consequence of a Washington-backed economic war.
The US welcomed the announcement as a "real opportunity" and said it would be "happy to put some of our aid into this method of reaching the Venezuelan people".
Hyperinflation and a lack of supplies has meant food and medicine are often unaffordable, leadingRead More – Source